Thrombotic Microangiopathy in IgA Nephropathy

Thrombotic Microangiopathy in IgA Nephropathy

Implication for health policy/practice/research/medical education: Thrombotic microangiopathy (TMA) occurs in IgA nephropathy, but is uncommon in the setting of IgA nephropathy. However, the reports of overlapping morphologic lesions of TMA and IgAN are poorly understood and debatable and needs more attention in larger series of IgAN. Copyright © 2013, Iranian Red Crescent Medical Journal; Publ...

thrombotic microangiopathy in iga nephropathy

A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy.

Thrombotic microangiopathy (TMA) occurs in IgA nephropathy, but its clinical significance is not well described. We retrospectively examined a series of 128 patients diagnosed with IgA nephropathy between 2002 and 2008 who had a mean follow-up of 44±27 months. In our series, 53% presented with lesions of TMA, acute or organized, in arteries and/or arterioles. Among patients with TMA, 4% were no...

HIV associated thrombotic microangiopathy.

Thrombotic microangiopathy (TMA) is a known complication of HIV infection. Endothelial cell injury appears to be the primary event causing platelet activation and deposition in the microvasculature. Direct cytopathic roles of HIV as well as other factors such as malignancy, drugs, and infectious agents have been implicated in the pathogenesis of HIV-TMA. Although the the majority of patients pr...

Pulmonary Tumor Thrombotic Microangiopathy

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare clinical entity where tumor cell embolisms in pulmonary circulation induce thrombotic microangiopathy (TMA), respiratory failure, and subacute cor pulmonale. We describe 3 cases of PTTM that presented as the initial manifestation of metastatic gastric adenocarcinoma with TMA and pulmonary infiltrates. All 3 cases had similar clinical a...